Shaping light lets 2D microscopes capture 4D data

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Fluorescent microscopy adds a new dimension with Rice University lab’s invention
Two years ago, the Rice lab of chemist Christy Landes introduced super temporal resolution microscopy, a technique that allowed researchers to image fluorescent molecules 20 times faster than traditional lab cameras normally allow. They’ve now developed a general method to let a microscope capture 3D spatial information along with the fourth dimension, molecular movement over time.

 Jeff Fitlow/Rice University)Rice University postdoctoral researcher Chayan Dutta sets up a microscope for new experiments with super temporal resolution microscopy, a technique the lab has advanced with the ability to make custom phase masks. Photo by Jeff Fitlow